| Identification | More | [Name]
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE | [CAS]
17833-43-1 | [Synonyms]
4-METHYLUMBELLIFERYL A-D-GLUCOPYRANOSIDE
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOSIDE
4-MU-ALPHA-D-GLC
7-HYDROXY-4-METHYLCUMARIN-ALPHA-D-GLUCOPYRANOSID
7-(.alpha.-D-glucopyranosyloxy)-4-methyl-2H-1-Benzopyran-2-one
4-METHYLUMBELLIFERYL-A-D-GLUCOSIDE
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE 99%
4-METHYLUMBELLIFERYL ALPHA-D-GLUCOSIDE CRYSTALLINE
4-methylumberiferryl-alpha-D-glucopyranoside
(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)α-D-glucopyranoside
4-Methyl-7-(α-D-glucopyranosyloxy)-2H-1-benzopyran-2-one
4-Methylumbeliferon α-D-glucoside | [EINECS(EC#)]
241-794-0 | [Molecular Formula]
C16H20O9 | [MDL Number]
MFCD03791281 | [Molecular Weight]
356.32 | [MOL File]
17833-43-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
171-173 °C
| [Boiling point ]
626.9±55.0 °C(Predicted) | [density ]
1.522±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 50 mg/mL, clear, colorless to faintly yellow
| [form ]
White solid | [pka]
12.73±0.70(Predicted) | [color ]
White to Off-White | [Usage]
A fluorogenic substrate in the assay of a-glucosidase. Has been used in the study of Pompe disease.
Fluorescence: max. Abs. 317nm; max. Em. 374nm; e x 10-3: 1 | [BRN ]
1690776 | [InChI]
InChI=1/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/s3 | [InChIKey]
YUDPTGPSBJVHCN-JZYAIQKZSA-N | [SMILES]
C12OC(C=C(C)C=1C=CC(O[C@@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)=C2)=O |&1:11,12,14,15,17,r| | [CAS DataBase Reference]
17833-43-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.1,2 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.3 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.1,2 | [Chemical Properties]
white to off-white crystalline powder | [Uses]
4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s). | [Uses]
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate in the assay of a-glucosidase,it has been used in the study of Pompe disease.
| [Definition]
ChEBI: 4-Methylumbelliferyl-alpha-D-glucopyranoside is a member of coumarins and a glycoside. | [Purification Methods]
Recrystallise 4-methylumbellifer-7-yl--D-glucopyranoside from hot H2O or EtOH. [Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 IV 443.] | [References]
[1] PETRA OLIVOVA . Effect of sample collection on α-galactosidase A enzyme activity measurements in dried blood spots on filter paper[J]. Clinica Chimica Acta, 2009, 403 1: Pages 159-162. DOI: 10.1016/j.cca.2009.02.008
[2] STEPHAN C.A. WENS . Remarkably low fibroblast acid α-glucosidase activity in three adults with Pompe disease[J]. Molecular genetics and metabolism, 2012, 107 3: Pages 485-489. DOI: 10.1016/j.ymgme.2012.09.003 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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