| Identification | More | [Name]
2-METHYLGLUTARIC ACID | [CAS]
18069-17-5 | [Synonyms]
2-METHYLGLUTARIC ACID
2-METHYLPENTANEDIOIC ACID
AKOS 237-134
ALPHA-METHYLGLUTARIC ACID
A-METHYLGLUTARIC ACID
RARECHEM AL BO 0092
Pentanedioic acid, 2-methyl-, (.+/-.)-
2-MethylglutaricAcid98% | [EINECS(EC#)]
210-521-7 | [Molecular Formula]
C6H10O4 | [MDL Number]
MFCD00002661 | [Molecular Weight]
146.14 | [MOL File]
18069-17-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to almost white fine crystalline powder | [Melting point ]
80-82 °C(lit.) | [Boiling point ]
214-215 °C22 mm Hg(lit.) | [density ]
1.4528 (rough estimate) | [refractive index ]
1.4336 (estimate) | [Fp ]
214-215°C/22mm | [form ]
powder | [BRN ]
1723219 | [InChI]
1S/C6H10O4/c1-4(6(9)10)2-3-5(7)8/h4H,2-3H2,1H3,(H,7,8)(H,9,10) | [InChIKey]
AQYCMVICBNBXNA-UHFFFAOYSA-N | [SMILES]
CC(CCC(O)=O)C(O)=O | [CAS DataBase Reference]
18069-17-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
Step 1: 80g diethyl malonate + 50mL DMF + 14g KF/Al2O3, oil bath 80℃, 50g methyl methacrylate dissolved in 50mL DMF was added dropwise, reaction for 5 hours. After the reaction, GC-MS analysis showed that most of the diethyl malonate was converted, and the chromatographic integral area percentage of the main intermediate was 56%. The solvents DMF and methanol were removed by vacuum distillation, and approximately 70g of product 1 was obtained by vacuum distillation at 160℃. Step 2: 0.1mol of product 1 was hydrolyzed with 0.4mol NaOH at 20℃ for 3 hours, then acidified with 0.4mol sulfuric acid, refluxed at 100℃ for decarboxylation for 4 hours, cooled, separated, and the aqueous phase was extracted with ethyl acetate 5 times. The organic phases were combined, the solvent was removed by vacuum, and GC-MS analysis showed that it was 2-methylglutaric acid (product 2). The chromatographic integral area percentage was 68%, and the yield was 60%. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29171990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white fine crystalline powder | [Uses]
2-Methylglutaric acid was used in the preparation of acetic acid. | [Definition]
ChEBI: 2-methylglutaric acid is an alpha,omega-dicarboxylic acid that is glutaric acid substituted at position 2 by a methyl group. It has a role as a mammalian metabolite. It is an alpha,omega-dicarboxylic acid and a dicarboxylic fatty acid. It is functionally related to a glutaric acid. It is a conjugate acid of a 2-methylglutarate(2-). | [Purification Methods]
Crystallise the acid from distilled water, then dry it under vacuum over conc H2SO4. [Beilstein 2 IV 1989.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|