| Identification | Back Directory | [Name]
Ald--Ph-PEG2-acid | [CAS]
1807534-84-4 | [Synonyms]
DF-PEG2-COOH
CHO-Ph-PEG2-acid
Ald-Ph-PEG2-COOH
Ald--Ph-PEG2-acid
ALD-PH-NH-PEG2-COOH
CHO-Ph-CONH-PEG2-acid
Ald-Ph-amido-PEG2-C2-acid
Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]- | [Molecular Formula]
C15H19NO6 | [MDL Number]
MFCD28122946 | [MOL File]
1807534-84-4.mol | [Molecular Weight]
309.31 |
| Chemical Properties | Back Directory | [Boiling point ]
568.4±50.0 °C(Predicted) | [density ]
1.248±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF | [pka]
4.27±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Ald-Ph-PEG2-acid is a small PEG reagent with a benzaldehyde moiety and a terminal carboxylic acid group. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can undergo reactions with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond. | [Uses]
Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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