| Identification | Back Directory | [Name]
Aminoxy-PEG3-Propargyl | [CAS]
1807537-27-4 | [Synonyms]
Aminoxy-PEG3-Alkyne
Aminooxy-PEG3-Alkyne
Aminoxy-PEG3-Propargyl
Aminooxy-PEG3-Propargyl
O-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)hydroxylamine | [Molecular Formula]
C9H17NO4 | [MDL Number]
MFCD28950771 | [MOL File]
1807537-27-4.mol | [Molecular Weight]
203.24 |
| Chemical Properties | Back Directory | [Boiling point ]
309.6±32.0 °C(Predicted) | [density ]
1.069±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.21±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG3-propargyl has a alkyne group and an aminooxy group. The aminooxy group reacts with aldehydes or ketones to form a stable oxime linkages. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry reactions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO2018204416A1. |
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