ChemicalBook--->CAS DataBase List--->1807537-27-4

1807537-27-4

1807537-27-4 Structure

1807537-27-4 Structure
IdentificationBack Directory
[Name]

Aminoxy-PEG3-Propargyl
[CAS]

1807537-27-4
[Synonyms]

Aminoxy-PEG3-Alkyne
Aminooxy-PEG3-Alkyne
Aminoxy-PEG3-Propargyl
Aminooxy-PEG3-Propargyl
O-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)hydroxylamine
[Molecular Formula]

C9H17NO4
[MDL Number]

MFCD28950771
[MOL File]

1807537-27-4.mol
[Molecular Weight]

203.24
Chemical PropertiesBack Directory
[Boiling point ]

309.6±32.0 °C(Predicted)
[density ]

1.069±0.06 g/cm3(Predicted)
[form ]

Liquid
[pka]

4.21±0.70(Predicted)
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

Aminooxy-PEG3-propargyl has a alkyne group and an aminooxy group. The aminooxy group reacts with aldehydes or ketones to form a stable oxime linkages. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry reactions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
[Uses]

Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

PEGs
[References]

[1] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO2018204416A1.
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