| Identification | Back Directory | [Name]
Propargyl-PEG3-Bromide | [CAS]
203740-63-0 | [Synonyms]
Alkyne-PEG3-Br
PROPARGYL-PEG3-BR
Propargyl-PEG3-Bromide
3-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)prop-1-yne
1-Propyne, 3-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- | [Molecular Formula]
C9H15BrO3 | [MDL Number]
MFCD28505517 | [MOL File]
203740-63-0.mol | [Molecular Weight]
251.12 |
| Chemical Properties | Back Directory | [Boiling point ]
287.8±25.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-bromide comprises a propargyl group and a bromide group. The propargyl group reacts with azide-bearing compounds or biomolecules in Click Chemistry to yield a stable triazole linkage; copper will be needed as a catalyst. | [Uses]
Propargyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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