| Identification | Back Directory | [Name]
Amino-PEG11-Amine | [CAS]
479200-82-3 | [Synonyms]
NH2-PEG11-NH2
PEG-12 diamine
Amino-PEG11-Amine
Amino-PEG12-amine
H2N-(CH2CH2O)12-NH2
NH2-PEG11-CH2CH2NH2
Amino-PEG11-Amine ISO 9001：2015 REACH
Undecaoxapentatriacontane-1,35-diamine
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine | [Molecular Formula]
C24H52N2O11 | [MDL Number]
MFCD28122961 | [MOL File]
479200-82-3.mol | [Molecular Weight]
544.68 |
| Chemical Properties | Back Directory | [Boiling point ]
591.2±45.0 °C(Predicted) | [density ]
1.084±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Oil | [pka]
9.04±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Amino-PEG11-Amine is a PEG reagents compring two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | [Uses]
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1]. | [IC 50]
PEGs | [References]
[1] Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15. DOI:10.1021/cb3006243 |
|
|