| Identification | Back Directory | [Name]
Angiotensin acetate | [CAS]
58-49-1 | [Synonyms]
DRVYVHPF
Angiotensin acetate
[VAL5]-ANGIOTENSIN II
Angiotensin II 5-valine
(5-L-Val)-Angiotensin II
[VAL5] ANGIOTENSIN II HUMAN
ANGIOTENSIN II, 5-L-VALINE-
ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH
[val5]-angiotensin ii acetate hydrate
[Val5]-Angiotensin II acetate salt hydrate
REF DUPL: H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH | [Molecular Formula]
C49H69N13O12 | [MDL Number]
MFCD00167495 | [MOL File]
58-49-1.mol | [Molecular Weight]
1032.15 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [density ]
1.45±0.1 g/cm3(Predicted) | [form ]
powder | [pka]
3.56±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : ≥ 257.5 mg/mL (249.48 mM) | [Sequence]
H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH | [InChIKey]
JVCJXRGXGITABA-IAQGTVMASA-N | [CAS DataBase Reference]
58-49-1 |
| Hazard Information | Back Directory | [Uses]
Angiotensin acetate is a biologically active peptide and a derivative of [5-?valine]?angiotensin II. | [Definition]
ChEBI: Val(5)-angiotensin II is an angiotensin II. | [Biochem/physiol Actions]
Angiotensin II analog that is an agonist AT1 angiotensin receptors. | [in vivo]
By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1]. | [storage]
-20°C, protect from light |
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