| Identification | More | [Name]
5-Methoxy-2-nitrobenzoic acid | [CAS]
1882-69-5 | [Synonyms]
2-nitro-5-methoxybenzoic acid
5-METHOXY-2-NITROBENZOIC ACID
6-Nitro-m-anisicacid
(R)-4-CHLOROMETHYL-2,2-DIMETHYL-1,3-DIOXOLANE 98+% | [Molecular Formula]
C8H7NO5 | [MDL Number]
MFCD00151836 | [Molecular Weight]
197.14 | [MOL File]
1882-69-5.mol |
| Questions And Answer | Back Directory | [Synthesis]
m-Methoxybenzaldehyde was added to nitric acid in batches, maintaining an internal temperature of 18-20°C. After the addition was complete, the temperature was raised to room temperature, and the reaction was allowed to proceed for 10 minutes with vigorous stirring. The reaction solution was then poured into 1000 ml of cold water, filtered, and the solid was neutralized with sodium hydroxide aqueous solution to a pH of 12. Potassium permanganate was added at 40°C, and the reaction was maintained at this temperature for 1 hour. The mixture was then filtered while hot, and the filtrate was dried to obtain 5-methoxy-2-nitrobenzoic acid. |
| Chemical Properties | Back Directory | [Appearance]
beige to grey or brown granules | [Melting point ]
125-130 °C (lit.) | [Boiling point ]
334.23°C (rough estimate) | [density ]
1.430 | [refractive index ]
1.5700 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Granules | [pka]
2.06±0.25(Predicted) | [color ]
Beige to gray or brown | [BRN ]
1877657 | [InChI]
InChI=1S/C8H7NO5/c1-14-5-2-3-7(9(12)13)6(4-5)8(10)11/h2-4H,1H3,(H,10,11) | [InChIKey]
URADKXVAIGMTEG-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC(OC)=CC=C1[N+]([O-])=O | [CAS DataBase Reference]
1882-69-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29182900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
beige to grey or brown granules | [Uses]
5-Methoxy-2-nitrobenzoic acid is used in the synthesis of Cathepsin S inhibitors with antitumor applications. In addition, 2-aminocombretastatin derivatives with potential as antimitotic agents are synt hesized using this compound.
| [General Description]
5-Methoxy-2-nitrobenzoic acid is a substituted 2-nitrobenzoic acid. It has been reported to be one of the microbial degradation metabolite of cypermethrin, a synthetic pyrethroid pesticide. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Maya High Purity Chemicals
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| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
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www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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