| Identification | Back Directory | [Name]
CARDAMONIN | [CAS]
18956-16-6 | [Synonyms]
Cardamoni
ARDAMONIN
-3-phenylprop-2-en-1-one
1-(2,4-Dihydroxy-6-methoxyphenyl)
(E)-1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-phenyl-
(E)-1-(2,4-DIHYDROXY-6-METHOXY-PHENYL)-3-PHENYL-PROPENONE
1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-phenylprop-2-en-1-one
2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-
Natural Alpinia Seed Extract 98% Cardamonin Powder CAS?18956-16-6 | [Molecular Formula]
C16H14O4 | [MDL Number]
MFCD00238554 | [MOL File]
18956-16-6.mol | [Molecular Weight]
270.28 |
| Chemical Properties | Back Directory | [Melting point ]
178 °C | [Boiling point ]
484.5±45.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: 125 mg/mL (462.48 mM) | [form ]
Solid | [pka]
7.00±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one is inhibits NO and PGE2 production and inhibits TXB2 production. | [Definition]
ChEBI: Cardamonin is a member of chalcones. | [in vivo]
Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice[4]. | Animal Model: | Male C57BL/6 J mice (8 weeks old, 20-22 g)[4] | | Dosage: | 20, 40 or 80 mg/kg | | Administration: | Oral gavage; 20, 40 or 80 mg/kg; once | | Result: | Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner. |
| Animal Model: | Male C57BL/6 J mice (8 weeks old, 20-22 g)[4] | | Dosage: | 20, 40 or 80 mg/kg | | Administration: | Oral gavage; 20, 40 or 80 mg/kg; once | | Result: | Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice. |
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