| Identification | More | [Name]
3',4',5,7-TETRAMETHOXYFLAVONE | [CAS]
855-97-0 | [Synonyms]
3',4',5,7-TETRAMETHOXYFLAVONE
5,7,3',4'-TETRAMETHOXYFLAVONE
LUTEOLIN TETRAMETHYL ETHER
5,7,3’,4’-tetramethylluteolin
Luteolinetetramethylether
LUTEOLIN TETRAMETHYLETHER(RG)
Tetramethoxyluteolin
Tetramethylluteolin | [Molecular Formula]
C19H18O6 | [MDL Number]
MFCD00017558 | [Molecular Weight]
342.34 | [MOL File]
855-97-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
195-197°C | [Boiling point ]
528.8±50.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO:6.85(Max Conc. mg/mL);20.0(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white | [Detection Methods]
NMR,HPLC | [BRN ]
336320 | [LogP]
3.360 (est) | [CAS DataBase Reference]
855-97-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1]. | [in vivo]
5,7,3',4'-Tetramethoxyflavone (25-100 mg/kg, i.g.) exhibits chondroprotective activity in rats[1].
5,7,3',4'-Tetramethoxyflavone (5-20 mg/kg; i.v., p.o.) has the absolute bioavailability of 14.3 % in rats[3].
1.19 Pharmacokinetic Analysis in Sprague-dawley Rats Model[3]| Route | Dose (mg/kg) | AUC (min μg/mL) | AUC/Dose (min/mL) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | Bioavailability (%) | | i.v. | 5 | 161.49 ± 58.78 | 0.1154 ± 0.0420 | 62.85 ± 27.92 | / | / | 14.3 | | p.o. | 50 | 231.43 ± 71.87 | 0.0165 ± 0.0051 | 273.76 ± 90.23 | 190.34 ± 24.50 | 0.79 ± 0.30 | / |
| Animal Model: | Rat knee OA model[1] | | Dosage: | 25-100 mg/kg | | Administration: | i.g. | | Result: | Decreased the contents of IL-1b, TNF-a, and PGE2 in a dose-dependent manner.
Decreases the expression of the inflammatory cytokines in rat knee osteoarthritis (OA) synovial fluid (SF) lavages.
Inhibited chondrocytes hypertrophy and decreased the cartilage thickness.
Exhibited down regulation of b-catenin in a dose-dependent manner.
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| [IC 50]
Plasmodium | [storage]
4°C, protect from light | [References]
[1] Wu L, et al. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452(3):682-8. DOI:10.1016/j.bbrc.2014.08.129
[2] Wu L, et al. 5,7,3',4'-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018 Mar;59(2):157-166. DOI:10.1080/03008207.2017.1321639
[3] Wei G, et al. Absolute bioavailability, pharmacokinetics and excretion of 5,7,30 ,40 -tetramethoxyflavone |
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