| Identification | More | [Name]
CREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE | [CAS]
19333-65-4 | [Synonyms]
CREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE
N-[IMINO(PHOSPHONOAMINO)METHYL]-N-METHYLGLYCINE DISODIUM SALT, HYDRATE
N-(PHOSPHONOAMIDINO)SARCOSINE ISODIUM SALT
PHOSPHOCREATINE DISODIUM SALT, HYDRATE
phosphocreatine disodium synthetic*preweighed via
PHOSPHOCREATINE DISODIUM HYDRATE
CREATINE PHOSPHATE DISODIUM SALT 4-HYDRATE
CREATINE PHOSPHATE DISODIUM SALT HEXAHYDRATE extrapure
Phosphocreatine hydrate disodium salt | [EINECS(EC#)]
213-074-6 | [Molecular Formula]
C4H20N3Na2O11P | [MDL Number]
MFCD00150193 | [Molecular Weight]
363.17 | [MOL File]
19333-65-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [storage temp. ]
−20°C
| [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
White crystalline | [color ]
White to off-white | [Water Solubility ]
water: 50mg/mL, clear, colorless | [InChI]
1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2 | [InChIKey]
KZVYPOKBYRXZKS-UHFFFAOYSA-L | [SMILES]
O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O | [CAS DataBase Reference]
19333-65-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline | [Uses]
Phosphocreatine disodium salt hydrate has been used:
- as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins
- of M5+?buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments
- of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay
| [General Description]
Creatine phosphate is a high-energy phosphate compound that stores energy from mitochondria whenever sufficient amounts of ATP are present. When ATP levels are low, energy from phosphocreatine is transferred to ADP molecules, which are quickly converted to ATP. It is often a component of ATP-generating systems. | [Biochem/physiol Actions]
Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells. | [in vivo]
Non-salt form:
Phosphocreatine (200 mg/kg, i.p., once every other day, 7 weeks) not only alleviates oxidative stress and myocardial apoptosis, but also rescues myocardial necroptosis in DOX-induced cardiotoxicity of rat[2].
Phosphocreatine (20-40 mg/kg, i.v., daily, 6 weeks) has a protective effect on the kidney tissues against diabetic nephropathy in SD (Sprague Dawley) rats[4].
| Animal Model: | Male Sprague Dawley (SD) rats, i.p., normal saline, 3 times; i.p., DOX 2 mg/kg, 7 times; i.p., normal saline, 3 times [2] | | Dosage: | 200 mg/kg | | Administration: | i.p., once every other day, 7 weeks | | Result: | Improved the heart function abnormality.
Lowered myocardial apoptosis.
Recovered the expression of Nrf2, SOD, FoxO3a and diminished C-Casp3, Bax/Bcl2 in the myocardial tissue of rats.
Markedly improved myocardial necroptosis, as indicated by decreasing expression of RIP3 and CaMKII.
Increased expression level of TAK1.
|
| Animal Model: | Male Sprague Dawley (SD) rats, i.p., 70 mg/kg (STZ(Streptozotocin) (HY-13753)), daily, 6 weeks [4] | | Dosage: | 20, 40 mg/kg | | Administration: | i.p., daily, 6 weeks | | Result: | Reduced hyperglycemia compared with STZ (Streptozotocin) (HY-13753) -treated rats.
Increased the weight of rats gradually compared with STZ (Streptozotocin) (HY-13753) group.
Decreased kidney weight index (kidney weight/body weight).
Decreased MDA level and increased of GSH and SOD levels compared with STZ group.
Decreased the apoptotic rate compared with MGO-treated groups.
|
| [IC 50]
Human Endogenous Metabolite |
|
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Sigma-Aldrich
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