1939-27-1

563-83-7

401-81-0

1939-27-1

GENERAL METHOD: A mixture of cobalt(II) oxalate dihydrate (Sigma-Aldrich, 0.294 mmol), Cs2CO3 (2.94 mmol), isobutyramide (1.47 mmol), DMEDA (0.588 mmol), distilled water (0.3 mL), and 3-iodobenzotrifluoride (2.205 mmol) was added to a reaction vial containing a polytetrafluoroethylene sealed screw cap in an 8.0 mL reaction flask. The reaction mixture was stirred in a closed system at 120°C to 130°C for 24 hours. The non-homogeneous mixture was then cooled to room temperature and diluted with CH2Cl2. The combined organic extracts were dried with anhydrous Na2SO4, filtered and the solvent removed under reduced pressure. The crude product was loaded onto a silica gel column using a minimal amount of CH2Cl2 and purified by column chromatography to afford N-(3-(trifluoromethyl)phenyl)isobutyramide. The structure and purity of the product were confirmed by 1H NMR and 13C NMR spectral analysis.