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1953-54-4

1953-54-4 Structure

1953-54-4 Structure
IdentificationMore
[Name]

5-Hydroxyindole
[CAS]

1953-54-4
[Synonyms]

1H-INDOL-5-OL
5-HYDROXYINDOLE
5-INDOLOL
INDOL-5-OL
TIMTEC-BB SBB004214
5-Hydroxy-1H-indole
Hydroxy-5 indole
hydroxy-5indole
Hydroxyindole,98%
5-hdroxyindole
5-HYDROXYINDOLE 99%
5-Hydroxyindole, 98+%
[EINECS(EC#)]

217-782-6
[Molecular Formula]

C8H7NO
[MDL Number]

MFCD00005677
[Molecular Weight]

133.15
[MOL File]

1953-54-4.mol
Chemical PropertiesBack Directory
[Appearance]

beige to brown crystalline needles or powder
[Melting point ]

106-108 °C(lit.)
[Boiling point ]

245.66°C (rough estimate)
[density ]

1.1475 (rough estimate)
[refractive index ]

1.5260 (estimate)
[storage temp. ]

0-6°C
[solubility ]

38g/l
[form ]

Crystalline Needles or Powder
[pka]

9.98±0.40(Predicted)
[color ]

beige
[Sensitive ]

Light Sensitive
[Detection Methods]

HPLC
[BRN ]

112349
[CAS DataBase Reference]

1953-54-4(CAS DataBase Reference)
[NIST Chemistry Reference]

Indol-5-ol(1953-54-4)
[Storage Precautions]

Store under nitrogen;Light sensitive
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
[WGK Germany ]

3
[RTECS ]

NM2430000
[HazardClass ]

IRRITANT, KEEP COLD
[HS Code ]

29339990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Palladium-->N,N-Dimethylformamide dimethyl acetal-->Benzyl bromide-->potassium ferricyanide-->3-Methyl-4-nitrophenol-->1-[2-(5-BENZYLOXY-2-NITROPHENYL)VINYL]PYRROLIDINE-->5-(prop-2-ynynloxy)indole-->2,3-DIHYDROINDOL-5-OL-->4-Benzyloxyphenylhydrazine-->5-Indolylboronic acid-->5-Methoxyindole-->2,6-Dimethylaniline-->5-Benzyloxyindole
[Preparation Products]

5-(6-Chloropyrimidin-4-yloxy)-1H-indole
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

5-Hydroxyindole(1953-54-4).msds
Hazard InformationBack Directory
[Chemical Properties]

beige to brown crystalline needles or powder
[Uses]

• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6
[Uses]

5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptop han (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
[Uses]

5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
[Definition]

ChEBI: 5-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group. It has a role as a human metabolite.
[Synthesis Reference(s)]

Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017
Spectrum DetailBack Directory
[Spectrum Detail]

5-Hydroxyindole(1953-54-4)MS
5-Hydroxyindole(1953-54-4)1HNMR
5-Hydroxyindole(1953-54-4)13CNMR
5-Hydroxyindole(1953-54-4)IR1
5-Hydroxyindole(1953-54-4)IR2
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

5-Hydroxyindole, 97%(1953-54-4)
[Alfa Aesar]

5-Hydroxyindole, 98+%(1953-54-4)
[Sigma Aldrich]

1953-54-4(sigmaaldrich)
[TCI AMERICA]

5-Hydroxyindole,>98.0%(GC)(1953-54-4)
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