| Identification | Back Directory | [Name]
Sulfamethazine sodium salt | [CAS]
1981-58-4 | [Synonyms]
sulmet
vesadin
bovibol
Sulfoxine 33
sodiumsulfadimidine
sodiumsulfametazine
sodiumsulfamethazine
sodiumsulfamezathine
SULFADIMIDINE SODIUM
sulfamethazinesodium
sodiumsulphamezathine
SODIUMSULPHAMETHAZINE
sodiumsulfamethiazine
Sulphadimidine Sodium Bp
SULFAMETHAZINE SODIUM SALT
SulfadiMidine Base(SodiuM)
SulfamethazineSodiumSalt>
Sulofamethazine Sodium Salt
Sulfadimethyldiazine Sodium Salt
SulfaMethazine sodiuM pyriMidine
Sulfamethazine sodium salt USP/EP/BP
SULFAMETHAZINE SODIUM (SULFADIMIDINE SODIUM)
SULFADIMIDINE SODIUM(SM2-NA)(NDC:56631-0901)
(n(sup1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-sodiu
n(sup1)-(4,6-dimethyl-2-pyrimidinyl)-sulfanilamidmonosodiumsalt
salesodicodella2-p-aminobenzensulfonamido-4,6-dimetil-pirimidina
sodium (4-aminophenyl)sulfonyl-(4,6-dimethyl-2-pyrimidinyl)azanide
4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide Sodium Salt
4-AMINO-N-[4,6-DIMETHYL-2-PYRIMIDINYL]BENZENE-SULFONAMIDE SODIUM SALT
4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamidmonosodiumsalt
Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt
BenzenesulfonaMide,4-aMino-N-(4,6-diMethyl-2-pyriMidinyl)-, sodiuM salt (1:1)
Sodium Sulfamethazine
4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide Sodium Salt | [EINECS(EC#)]
217-840-0 | [Molecular Formula]
C12H13N4NaO2S | [MDL Number]
MFCD00068333 | [MOL File]
1981-58-4.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Melting point ]
>288°C (dec.) | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble50mg/mL | [form ]
powder | [color ]
white to off-white | [Water Solubility ]
H2O: soluble 50mg/mL | [Merck ]
14,8915 | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);; | [InChIKey]
WIVZAHIZHZEEOX-UHFFFAOYSA-N | [SMILES]
S(C1C=CC(N)=CC=1)(=O)(=O)NC1=NC(C)=CC(C)=N1.[NaH] | [CAS DataBase Reference]
1981-58-4 | [EPA Substance Registry System]
Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2- pyrimidinyl)-, monosodium salt(1981-58-4) |
| Hazard Information | Back Directory | [Uses]
Antibacterial;Inhibitor of folic acid synthesis | [Chemical Properties]
White or milky white crystalline powder, odorless or almost odorless, easily soluble in water, slightly soluble in ethanol. | [Biological Activity]
Sulfamethazine is an antimicrobial sulfur drug th at blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA)which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokineticsmetabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic. | [in vivo]
Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. | Animal Model: | 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] | | Dosage: | 80 mg/kg | | Administration: | Intravenous injection (Pharmacokinetic study) | | Result: | The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
|
| [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3
| [RTECS ]
WO9300000
| [TSCA ]
TSCA listed | [HS Code ]
2933.59.8000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
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