| Identification | Back Directory | [Name]
A-196 | [CAS]
1982372-88-2 | [Synonyms]
A-196
SGC A-196
A-196
(A196
A-196;A 196;A196
6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)- | [Molecular Formula]
C18H16Cl2N4 | [MOL File]
1982372-88-2.mol | [Molecular Weight]
359.25 |
| Chemical Properties | Back Directory | [Boiling point ]
584.6±45.0 °C(Predicted) | [density ]
1.399±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO (up to 5 mg/ml) | [form ]
powder | [pka]
3.96±0.30(Predicted) | [color ]
white to light brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | [InChI]
1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24) | [InChIKey]
ABGOSOMRWSYAOB-UHFFFAOYSA-N | [SMILES]
ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1 |
| Safety Data | Back Directory | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Description]
A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here. | [Uses]
A-196 is a potent inhibitor of SUV420H1. | [Biochem/physiol Actions]
A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | [storage]
Store at +4°C | [References]
1) Bromberg?et al.?(2017),?The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol.?13?317 |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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