| Identification | More | [Name]
H-D-PHG-OME HCL | [CAS]
19883-41-1 | [Synonyms]
D-(-)-ALPHA-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
D-ALPHA-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
D-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
D-PHENYLGLYCINE-OME HCL
H-D-PHG-OME HCL
(R)-(-)-2-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
methyl (R)-aminophenylacetate hydrochloride
R-phenylglycine methyl ester hydrochloride
D-Phenylglycine Methyl Ester HCl
R-Phenyl Glycine methyl ester HCL
(r)-(-)-à-aminophenylacetic acid methyl ester hydrochloride
d-(-)-à-phenylglycine methyl ester hydrochloride
D-(-)-A-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
D-Phenylglycine methyl ester hydrochlorid
D-(-)-ɑ-Phenylglycine methyl ester hydrochloride, 96%
D-(-)-alpha-Phenylglycine methyl ester hydrochloride, 98+%
2-phenylglycine methyl ester hydrochloride
(R)-(-)-2-phenylglycine methyl ester Hydrochloride ,98%
D-Phenylycine methyl ester hydrichloride
D-Phenylglycine methyl·hydrochloric acid | [EINECS(EC#)]
243-399-9 | [Molecular Formula]
C9H12ClNO2 | [MDL Number]
MFCD00137487 | [Molecular Weight]
201.65 | [MOL File]
19883-41-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
189-191 °C(lit.) | [alpha ]
-118o (C=1 IN H2O) | [storage temp. ]
2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder to crystal | [color ]
White to Almost white | [Optical Rotation]
[α]20/D 118°, c = 1 in H2O | [Detection Methods]
T | [BRN ]
3915654 | [Major Application]
peptide synthesis | [InChI]
InChI=1/C9H11NO2.ClH/c1-12-9(11)8(10)7-5-3-2-4-6-7;/h2-6,8H,10H2,1H3;1H/t8-;/s3 | [InChIKey]
DTHMTBUWTGVEFG-DDWIOCJRSA-N | [SMILES]
C(OC)(=O)[C@H](C1=CC=CC=C1)N.[H]Cl |&1:4,r| | [CAS DataBase Reference]
19883-41-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [HS Code ]
29224999 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
(R)-(-)-2-Phenylglycine Methyl Ester Hydrochloride is an intermediate in the synthesis of Cephradine, a cephalosporin antibiotic. It functions as an acyl donor in the enzymatic synthetic process for cephradine synthesis. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Methylation reaction of L-phenylglycine. L-phenylglycine (1 g, 6.05 mmol, 1.0 eq.) was suspended in methanol (25 mL) and cooled to 0°C. Thionyl chloride (475 μL, 6.66 mmol, 1.5 eq.) was slowly added. after 10 min, the reaction mixture was heated to 75 °C and refluxed for 2 h. The reaction was completed by TLC. After completion of the reaction (monitored by TLC), the solvent was removed under vacuum to give a white solid, L-phenylglycine methyl ester hydrochloride (1.23 g, quantitative yield). | [References]
[1] Tetrahedron, 1999, vol. 55, # 11, p. 3337 - 3354
[2] European Journal of Organic Chemistry, 2009, # 30, p. 5185 - 5191
[3] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[4] Tetrahedron, 2009, vol. 65, # 6, p. 1200 - 1206
[5] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992, # 8, p. 1279 - 1285 |
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