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2018-66-8

2018-66-8 Structure

2018-66-8 Structure
IdentificationMore
[Name]

N-Cbz-L-Leucine
[CAS]

2018-66-8
[Synonyms]

BENZYLOXYCARBONYL-L-LEUCINE
CBZ-LEUCINE
CBZ-LEU-OH
CBZ-L-LEUCINE
CBZ-L-LEU-OH
N-ALPHA-BENZYLOXYCARBONYL-L-LEUCINE
N-ALPHA-CARBOBENZOXY-L-LEUCINE
N-ALPHA-CBZ-L-LEUCINE
N-BENZYLOXYCARBONYL-L-LEUCINE
N-CARBOBENZOXY-L-LEUCINE
N-CARBOBENZYLOXY-L-LEUCINE
N-CBZ-L-LEUCINE
N-CBZ-L-LEUCINE-OH
Z-LEUCINE
Z-LEU-OH
Z-L-LEUCINE
Z-L-LEU-OH
benzyloxycarbonylleucine
carbobenzoxyleucine
carbobenzoxy-l-leucine
[EINECS(EC#)]

217-960-3
[Molecular Formula]

C14H19NO4
[MDL Number]

MFCD00026494
[Molecular Weight]

265.3
[MOL File]

2018-66-8.mol
Chemical PropertiesBack Directory
[Appearance]

yellow oil or weak solid
[alpha ]

-17 º (c=2, ethanol)
[Boiling point ]

408.52°C (rough estimate)
[density ]

1 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.512(lit.)
[Fp ]

85 °F
[storage temp. ]

2-8°C
[solubility ]

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
[form ]

viscous liquid
[pka]

4.00±0.21(Predicted)
[color ]

Colorless to Light yellow
[Specific Gravity]

1.0
[Optical Rotation]

[α]20/D 17°, c = 2 in ethanol
[Water Solubility ]

Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.
[BRN ]

1253861
[CAS DataBase Reference]

2018-66-8(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Flame (GHS02)Health Hazard (GHS08)
GHS02,GHS08
[Signal word ]

Warning
[Hazard statements ]

H226-H351-H361d
[Precautionary statements ]

P210-P280-P370+P378
[Hazard Codes ]

Xn
[Risk Statements ]

R10:Flammable.
R20/22:Harmful by inhalation and if swallowed .
R37/38:Irritating to respiratory system and skin .
R40:Limited evidence of a carcinogenic effect.
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
[RIDADR ]

UN 1993 3/PG 3
[WGK Germany ]

3
[RTECS ]

OH2921000
[HS Code ]

29242990
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Z-Leu-OH(2018-66-8).msds
Hazard InformationBack Directory
[Chemical Properties]

yellow oil or weak solid
[Uses]

Reactant for:
  • Peptide-based preparation of potential antitumor agents
  • Preparation of cyclopropyl peptidomimetics
  • Peptide synthesis
[Definition]

ChEBI: A L-leucine derivative obtained by the substitution of a benzyloxycarbonyl group on the nitrogen atom.
[reaction suitability]

reaction type: solution phase peptide synthesis
Spectrum DetailBack Directory
[Spectrum Detail]

N-Cbz-L-Leucine(2018-66-8)MS
N-Cbz-L-Leucine(2018-66-8)1HNMR
N-Cbz-L-Leucine(2018-66-8)IR1
N-Cbz-L-Leucine(2018-66-8)IR2
N-Cbz-L-Leucine(2018-66-8)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

N-Carbobenzyloxy-L-leucine, 95%(2018-66-8)
[Alfa Aesar]

N-Benzyloxycarbonyl-L-leucine, 98+% (dry wt.), may cont. up to ca 5% solvent(2018-66-8)
[Sigma Aldrich]

2018-66-8(sigmaaldrich)
[TCI AMERICA]

N-Carbobenzoxy-L-leucine,>96.0%(T)(2018-66-8)
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