| Identification | More | [Name]
2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one | [CAS]
20348-09-8 | [Synonyms]
2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE
LABOTEST-BB LT00451615
TIMTEC-BB SBB006815
2H-PYRIDO(3,2-B)-1,4-OXAZIN-3(4H)-ONE 95 %
4H-Pyrido[3,2-b][1,4]oxazin-3-one
3,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine-3-one | [EINECS(EC#)]
243-751-1 | [Molecular Formula]
C7H6N2O2 | [MDL Number]
MFCD00006697 | [Molecular Weight]
150.13 | [MOL File]
20348-09-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
204-206 °C(lit.) | [Boiling point ]
384.2±37.0 °C(Predicted) | [density ]
1.327±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
liquid | [pka]
11.06±0.20(Predicted) | [Appearance]
Off-white to light brown Solid | [BRN ]
1074010 | [CAS DataBase Reference]
20348-09-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Uses]
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one was used in the synthesis of quinazolinbenzoxazine derivatives. | [Synthesis]
A reaction mixture was prepared by mixing a solution of 2-amino-3-hydroxypyridine (45 mmol) and sodium bicarbonate (51 mmol) in water (30 mL) with 2-butanone (30 mL). A solution of 2-butanone (10 mL) with chloroacetyl chloride (51 mmol) was slowly added dropwise under ice-bath cooling conditions, and the rate of dropwise acceleration was controlled to keep the reaction temperature from exceeding 10°C. The reaction was carried out at room temperature. After dropwise addition, stirring was continued at room temperature for 30 min, and then the reaction was warmed up to 75°C for 1 hr. Upon completion of the reaction, the reaction solution was concentrated and purified by recrystallization (methanol/water=1:1) to afford 4.3 g of the target product 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one. | [References]
[1] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 2, p. 133 - 142
[2] Helvetica Chimica Acta, 1976, vol. 59, p. 1593 - 1612
[3] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0605-0607 |
|
|