| Identification | More | [Name]
Piroctone olamine | [CAS]
68890-66-4 | [Synonyms]
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
OCTOPIROX
PIROCTONE OLAMINE
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1)
2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1)
4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon
octopiroxolamine
PIROCTONE OLEAMINE
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Piroctone olamine (OCTO)
Piorctone Olamine
1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)2(1H)-PYRIDONE.
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone·2-aminoethanol
2-Aminoethanol/1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone,(1:1) | [EINECS(EC#)]
272-574-2 | [Molecular Formula]
C16H30N2O3 | [MDL Number]
MFCD01690792 | [Molecular Weight]
298.42 | [MOL File]
68890-66-4.mol |
| Questions And Answer | Back Directory | [Description]
Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone. | [Appearance]
White or slightly yellow crystalline powder.
| [Solubility]
Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.
| [Toxicity]
Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.
Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).
Chronic toxicity and carcinogencity : Negative.
Mutagenicity : Negative.
Irritation to skin and eye : Very low.
|
| Chemical Properties | Back Directory | [Melting point ]
134.0 to 138.0 °C | [Boiling point ]
135-235℃[at 101 325 Pa] | [density ]
1.1[at 20℃] | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly, Sonicated), Methanol (Slightly) | [form ]
neat | [pka]
5.9-7.4[at 20 ℃] | [color ]
White to Off-White | [Water Solubility ]
400-50000mg/L at 20-25℃ | [Merck ]
14,7502 | [InChI]
InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2 | [InChIKey]
BTSZTGGZJQFALU-UHFFFAOYSA-N | [SMILES]
C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C | [LogP]
1.05-3.86 at 20-25℃ | [CAS DataBase Reference]
68890-66-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.
| [Definition]
ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone. | [Brand name]
Octopirox (Hoechst AG, Germany). |
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