| Identification | More | [Name]
Arctiin | [CAS]
20362-31-6 | [Synonyms]
2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]-3-[[4-(-D-GLUCOPYRANOSYLOXY)-3-METHOXYPHENYL]METHYL]DIHYDRO-, (3R,4R)-
ARCTIGENIN-O-BETA-D-GLUCOPYRANOSIDE
(-)-ARCTIIN
ARCTIIN
ARCTIIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]-3-[[4-(-D-GLUCOPYRANOSYLOXY)-3-METHOXYPHENYL]METHYL]DIHYDRO-, (3R,4R)-,
ARCTIIN(P)
(-)-Arctin,Arctiumlappa
2 (3H)-Furanone, 4-[(3, 4-dimethoxyphenyl)methyl]-3-[[4-(.beta.-D-gluc opyranosyloxy)-3-met hoxyphenyl]methyl]dihydro-, (3R-trans)-
Arctin
Arctlin
(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(beta-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]
methyl]dihydro-, (3R,4R)- | [Molecular Formula]
C27H34O11 | [MDL Number]
MFCD00870630 | [Molecular Weight]
534.55 | [MOL File]
20362-31-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
107.0 to 111.0 °C | [Boiling point ]
756.4±60.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
White to off-white solid. | [pka]
12.83±0.70(Predicted) | [color ]
White to Off-White | [λmax]
278nm(EtOH)(lit.) | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [Cosmetics Ingredients Functions]
ANTIOXIDANT | [InChIKey]
XOJVHLIYNSOZOO-SWOBOCGESA-N | [SMILES]
[C@@H]1(COC(=O)[C@@H]1CC1=CC=C(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO)O2)O)C(OC)=C1)CC1=CC=C(OC)C(OC)=C1 |&1:0,5,12,13,15,16,18,r| | [LogP]
-0.564 (est) | [CAS DataBase Reference]
20362-31-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, derived from Arctium lappa, Forsythia suspensa, and Trachelospermum chinense. | [Uses]
Arctiin is a phytochemical acting as a UV filter. It protects against UVB radiation exposure. | [Definition]
ChEBI: Arctiin is a glycoside and a lignan. | [Biological Activity]
Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cellssuch as osteosarcomalungcolorectalcervicalbreastmelanomaand prostate cancer. Arctiin has also shown antiviral activity against influenza A when used alone or in combination with oseltamivir. Arctiin plays an important role in the process of inflammationby preventing the release of nitric oxideprostaglandin E2TNF-α (tumor necrosis factor - α)interleukin (IL)-1β and IL-6. A study using r at model shows th at arctiin possess anti-diabetic activity and might serve as an inhibitor of diabetic retinopathy.''Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cellssuch as osteosarcomalungcolorectalcervicalbreastmelanomaand prostate cancer. Arctiin has also shown antiviral activity against influenza A when used along or in combination with oseltamivir. | [in vivo]
Arctiin (120 mg/kg for p.o.;Once daily for 3 weeks) significantly improves cBSA-induced glomerulonephritis in glomerulonephritis rat model[4]. | Animal Model: | Glomerulonephritis rat model[4] | | Dosage: | 30, 60, and 120 mg/kg | | Administration: | Oral gavage (p.o.);Once daily for 3 weeksv | | Result: | Significantly decreased the levels of urine protein.
Markedly ameliorated the renal function.
Dramatically reduced IL-6 and TNF-a concentration in rat serum.
Dramatically decreased the NF-kB DNA binding activity.
Significantly reduced the MDA level and increased the SOD activity. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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