| Identification | Back Directory | [Name]
NK-3201 | [CAS]
204460-24-2 | [Synonyms]
NK-3201
N-(3,4-dioxo-1-phenyl-7-pyridin-2-yloxyheptan-2-yl)-2-(5-formamido-6-oxo-2-phenylpyrimidin-1-yl)acetamide
1(6H)-Pyrimidineacetamide, N-[2,3-dioxo-1-(phenylmethyl)-6-(2-pyridinyloxy)hexyl]-5-(formylamino)-6-oxo-2-phenyl- | [Molecular Formula]
C31H29N5O6 | [MDL Number]
MFCD03700768 | [MOL File]
204460-24-2.mol | [Molecular Weight]
567.59 |
| Hazard Information | Back Directory | [Description]
NK3201 is a specific chymase inhibitor, which suppresses bleomycin-induced pulmonary fibrosis in hamsters. | [Uses]
NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein[1][2]. | [References]
[1] Sakaguchi M, et al. A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters. Eur J Pharmacol. 2004 Jun 16;493(1-3):173-6. DOI:10.1016/j.ejphar.2004.04.024
[2] Takai S, et al. Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein. Life Sci. 2001 Aug 31;69(15):1725-32. DOI:10.1016/s0024-3205(01)01255-3 |
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