| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- | [CAS]
204592-94-9 | [Synonyms]
LY377604
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- | [Molecular Formula]
C31H32N4O4 | [MDL Number]
MFCD30187496 | [MOL File]
204592-94-9.mol | [Molecular Weight]
524.61 |
| Chemical Properties | Back Directory | [Boiling point ]
809.4±65.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.94±0.20(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. | [in vivo]
Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats[1]. | [References]
[1] Jesudason CD, et al. Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2(8):583-6. DOI:10.1021/ml200071k |
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