| Identification | More | [Name]
6-Methoxyguanine | [CAS]
20535-83-5 | [Synonyms]
2-AMINO-6-METHOXYPURINE
6-methoxy-1h-purin-2-amine
6-Methoxyguanine
O6-METHYLGUANINE
O-METHYLGUANINE
2-amino-6-methoxy-purin
6-methoxy-1h-purin-2-amin
6-methoxy-1h-purine-2-amine
o(sup6)-methylguanine
6-O-Methylguanine
Aminomethoxypurine,97%
2-Amino-6-methoxy-9H-purine
2-AMINO-6-METHOXYPURINE 97+%
6-methoxy-9h-purin-2-amine
NSC 37364
2-Amino-6-methoxypurine, 6-Methoxyguanine
6-Methoxy-7H-purin-2-amine | [EINECS(EC#)]
606-576-5 | [Molecular Formula]
C6H8N5O2 | [MDL Number]
MFCD00133009 | [Molecular Weight]
182.16 | [MOL File]
20535-83-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white solid | [Melting point ]
>300 °C(lit.)
| [Boiling point ]
598.5±53.0 °C(Predicted) | [density ]
1.531±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly, Heated), Water (Slightly, Heated) | [form ]
Solid | [pka]
9.74±0.10(Predicted) | [color ]
Off-White to Pale Yellow | [Usage]
Antitumor agent | [BRN ]
645384 | [InChI]
InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11) | [InChIKey]
BXJHWYVXLGLDMZ-UHFFFAOYSA-N | [SMILES]
N1C2C(=NC(N)=NC=2OC)NC=1 | [CAS DataBase Reference]
20535-83-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white solid | [Uses]
Antitumor agent | [Application]
6-O-Methyl-guanine is a key molecular tool for studying DNA damage, repair mechanisms, and cancer chemotherapy. It is a potent mutagenic and carcinogenic DNA damage product induced by alkylating agents (such as certain environmental carcinogens and chemotherapeutic drugs). It can mispair with thymine (T), leading to G:C to A:T base transition mutations during DNA replication. Therefore, O⁶-MeG is widely used in in vitro and cellular experiments to simulate DNA damage states and study how cells remove this damage through repair proteins such as O⁶-methylguanine-DNA methyltransferase (MGMT). | [Definition]
ChEBI: A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as
endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA. | [General Description]
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|