| Identification | Back Directory | [Name]
Hydroxy-PEG9-t-butyl ester | [CAS]
2055042-66-3 | [Synonyms]
HO-PEG9-COOtBu
CAS_2055042-66-3
Hydroxy-PEG9-Boc
HO-PEG9-CH2CH2COOtBu
Hydroxy-PEG9-t-butyl ester
4,7,10,13,16,19,22,25,28-Nonaoxatriacontanoic acid, 30-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C25H50O12 | [MDL Number]
MFCD30182029 | [MOL File]
2055042-66-3.mol | [Molecular Weight]
542.66 |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG9-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|