| Identification | More | [Name]
5-Bromovaleric acid | [CAS]
2067-33-6 | [Synonyms]
5-BROMO-N-VALERIC ACID
5-BROMOPENTANOIC ACID
5-BROMOVALERIC ACID
RARECHEM AL BO 0181
5-bromo-pentanoicaci
delta-Bromovaleric acid
Pentanoic acid, 5-bromo-
2-BROMOVALERIC ACID 97%
5-BROMOVALENC ACID
5-Bromovaleric acid, 97+%
5-Bromo-n-pentanoic acid
1-Bromo-4-carboxybutane | [EINECS(EC#)]
218-185-3 | [Molecular Formula]
C5H9BrO2 | [MDL Number]
MFCD00004414 | [Molecular Weight]
181.03 | [MOL File]
2067-33-6.mol |
| Chemical Properties | Back Directory | [Appearance]
yellowish to light brown crystals or cryst. powder | [Melting point ]
38-40 °C (lit.) | [Boiling point ]
142-145 °C (13 mmHg)
| [density ]
1.4210 (rough estimate) | [refractive index ]
1.4790 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
95% ethanol: soluble50mg/mL, clear, colorless to faintly yellow | [form ]
Crystals or Crystalline Powder | [pka]
4?+-.0.10(Predicted) | [color ]
Yellow to light brown | [Water Solubility ]
Soluble in ethanol. Insoluble in water. | [BRN ]
1745664 | [InChI]
1S/C5H9BrO2/c6-4-2-1-3-5(7)8/h1-4H2,(H,7,8) | [InChIKey]
WNXNUPJZWYOKMW-UHFFFAOYSA-N | [SMILES]
OC(=O)CCCCBr | [CAS DataBase Reference]
2067-33-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Valeric acid, 5-bromo(2067-33-6) | [EPA Substance Registry System]
2067-33-6(EPA Substance) |
| Questions And Answer | Back Directory | [Preparation]
In a 250 mL three-necked flask equipped with a stirrer and thermometer, a dichloromethane solution of 5-bromopentanol and the crown ether catalyst were added. The stirrer was started, and finely ground potassium permanganate was added in small batches while stirring rapidly, which took about 1 hour. After the addition was complete, stirring continued until the reaction temperature no longer rose. The reaction time was then determined using a TLC plate (different polarities diffuse at different rates on the plate). Using n-butanol:acetic acid:water = 4:1:1 as the developing solvent, the plate was spotted every 0.5 hours, ultimately determining that the reaction was complete after 1 hour. During the reaction, a large amount of manganese dioxide precipitate was produced. The reaction mixture was filtered, washed with water to remove the aqueous phase, and then washed with NaOH solution to remove the crown ether and CH2Cl2. The sodium 5-bromopentanate in the aqueous phase was then washed with acid, and the bottom layer was taken out to obtain the initial product. After drying, 16.2 g of 5-Bromovaleric acid was obtained, with a yield of 90%. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN3261 | [WGK Germany ]
3
| [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159080 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
5-Bromovaleric acid(2067-33-6) is an important raw material for organic synthesis and a commonly used reagent for chemical reactions. It can be used in the synthesis of the natural mosquito egg-laying pheromone red-6-acetoxy-5-hexadecanolactone, alkylammonium amphoteric amino acid derivatives and water-soluble nanoplatelets.
| [Chemical Properties]
yellowish to light brown crystals or cryst. powder | [Application]
5-Bromovaleric acid(2067-33-6) was used in the preparation of:
-
5-(3-dimethylammonio)propylammonio pentanoate bromide via reaction with 1,1-dimethyl-1,3-propylenediamine
-
nanodiamond functionalized by carboxylic acid groups
-
water-soluble nanoplatelets of potassium graphite
| [Uses]
5-Bromovaleric acid(2067-33-6) is used in the synthesis of inhibitors for aminoglycoside resistant bacteria. 5-Bromovaleric acid is also used in the preparation of sequence specific base pair mimics as topoisomerase IB inhibitors.
| [Purification Methods]
Crystallise the acid from pet ether. [Beilstein 2 IV 883.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|