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2095128-17-7

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2095128-17-7 Structure

2095128-17-7 Structure
IdentificationBack Directory
[Name]

MA-0204
[CAS]

2095128-17-7
[Synonyms]

MA-0204
CS-2841
Hexanoic acid, 3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-, (3R)-
[Molecular Formula]

C25H27F3N2O4
[MDL Number]

MFCD31807611
[MOL File]

2095128-17-7.mol
[Molecular Weight]

476.49
Chemical PropertiesBack Directory
[Boiling point ]

611.9±65.0 °C(Predicted)
[density ]

1.23±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

4.76±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].
[in vivo]

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1].

[IC 50]

PPARδ: 0.4 nM (EC50, in human); PPARδ: 7.9 nM (EC50, in mouse); PPARδ: 10 nM (EC50, in rat)
[References]

[1] Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. DOI:10.1021/acsmedchemlett.8b00287
Spectrum DetailBack Directory
[Spectrum Detail]

MA-0204(2095128-17-7)1HNMR
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