| Identification | Back Directory | [Name]
N2-iso-Butyroyl-2'-O-propargylguanosine | [CAS]
2095417-55-1 | [Synonyms]
N2-iso-Butyroyl-2'-O-propargylguanosine | [Molecular Formula]
C17H21N5O6 | [MDL Number]
MFCD28976148 | [MOL File]
2095417-55-1.mol | [Molecular Weight]
391.379 |
| Hazard Information | Back Directory | [Uses]
N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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