| Identification | Back Directory | [Name]
N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine | [CAS]
440327-50-4 | [Synonyms]
N2-iBu-2'-O-MOE-Gr
2’-MOE-N2-iBu-Guanosine
N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine
Guanosine, 2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-
N-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide | [Molecular Formula]
C17H25N5O7 | [MOL File]
440327-50-4.mol | [Molecular Weight]
411.41 |
| Hazard Information | Back Directory | [Uses]
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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