| Identification | Back Directory | [Name]
(2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [CAS]
2097381-86-5 | [Synonyms]
cis VH 298
(2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C27H33N5O4S | [MOL File]
2097381-86-5.mol | [Molecular Weight]
523.65 |
| Hazard Information | Back Directory | [Uses]
cis VH-298 is the cis form of VH-298 (HY-100947). cis VH-298 results in a significant loss of binding specificity of hydroxylated HIF-1a peptides to VHL in vitro[1]. | [IC 50]
VHL | [storage]
Store at -20°C | [References]
[1] Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312. DOI:10.1038/ncomms13312 |
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