| Identification | Back Directory | [Name]
AC-LEHD-AFC | [CAS]
210345-03-2 | [Synonyms]
AC-LEHD-AFC
AC-LEU-GLU-HIS-ASP-AFC
CASPASE-9 SUBSTRATE I, FLUOROGENIC
CASPASE 9 SUBSTRATE 1F, FLUOROGENIC
AC-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
N-ACETYL-LEU-GLU-HIS-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
N-ACETYL-LEU-GLU-HIS-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
N-ACETYL-LEU-GLU-HIS-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- (9CI)
4-[(2-acetamido-4-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid | [Molecular Formula]
C33H38F3N7O11 | [MDL Number]
MFCD01862610 | [MOL File]
210345-03-2.mol | [Molecular Weight]
765.69 |
| Chemical Properties | Back Directory | [Boiling point ]
1211.9±65.0 °C(Predicted) | [density ]
1.457±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO/DMF: 20 mM | [form ]
powder | [pka]
4.07±0.10(Predicted) | [color ]
white | [Water Solubility ]
Soluble to 1 mg/ml in water | [InChIKey]
HULKIXRFKRCRHD-ZJZGAYNASA-N | [SMILES]
FC(F)(F)C1=CC(=O)Oc2c1ccc(c2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc3[nH]cnc3)CC(=O)O |
| Hazard Information | Back Directory | [Uses]
Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death. | [Biological Activity]
Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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