ChemicalBook--->CAS DataBase List--->210345-02-1

210345-02-1

210345-02-1 Structure

210345-02-1 Structure
IdentificationBack Directory
[Name]

AC-LEU-GLU-THR-ASP-AFC
[CAS]

210345-02-1
[Synonyms]

AC-LETD-AFC
AC-LEU-GLU-THR-ASP-AFC
AC-LEU-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
N-ACETYL-LEU-GLU-THR-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
N-Acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
L-α-Asparagine,N-acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- (9CI)
4-[(2-acetamido-4-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoicacid
[Molecular Formula]

C31H38F3N5O12
[MDL Number]

MFCD07780890
[MOL File]

210345-02-1.mol
[Molecular Weight]

729.65
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

DMSO: 10 mg/ml
[form ]

White to off-white powder.
[Appearance]

Solid Powder
Hazard InformationBack Directory
[Description]

Ac-LETD-AFC is a fluorogenic substrate for caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

[Uses]

N-Acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine is a caspase substrate that is cleaved by caspase-8.
[Excitation / Emission Maximum]

400 nm/505 nm
[Sequene]

Ac-Leu-Glu-Thr-Asp-Unk
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