| Identification | Back Directory | [Name]
BMY 7378 | [CAS]
21102-94-3 | [Synonyms]
BMY 7378
8-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione | [Molecular Formula]
C22H31N3O3 | [MDL Number]
MFCD00153771 | [MOL File]
21102-94-3.mol | [Molecular Weight]
385.5 |
| Chemical Properties | Back Directory | [Boiling point ]
585.6±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [pka]
7.15±0.10(Predicted) | [InChI]
InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3 | [InChIKey]
AYYCFGDXLUPJAQ-UHFFFAOYSA-N | [SMILES]
C1C2(CC(=O)N(CCN3CCN(C4=CC=CC=C4OC)CC3)C(=O)C2)CCC1 |
| Hazard Information | Back Directory | [Uses]
BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2]. | [Definition]
ChEBI:8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione is a member of piperazines. | [References]
[1] Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275(3):1583-1589. PMID:8531132
[2] Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272(2-3):R5-R6. DOI:10.1016/0014-2999(94)00751-r |
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