| Identification | Back Directory | [Name]
PKUMDL-LC-101-D04 | [CAS]
2143896-83-5 | [Synonyms]
PKUMDL-LC-101-D04
GPX4-Activator-1d4
PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04 | [Molecular Formula]
C14H23ClN4O2S2 | [MOL File]
2143896-83-5.mol | [Molecular Weight]
378.93 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear |
| Hazard Information | Back Directory | [Description]
PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death. | [Uses]
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2]. | [storage]
Store at -20°C | [References]
1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019). |
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