| Identification | Back Directory | [Name]
m-PEG4-DBCO | [CAS]
2228857-36-9 | [Synonyms]
m-PEG4-DBCO
m-PEG4-NH-DBCO
mPEG4-DBCO,mPEG4-ADIBO,mPEG4-Dibenzocycolctyne | [Molecular Formula]
C28H34N2O6 | [MDL Number]
MFCD31654033 | [MOL File]
2228857-36-9.mol | [Molecular Weight]
494.59 |
| Chemical Properties | Back Directory | [Boiling point ]
746.8±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
15.14±0.46(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C28H34N2O6/c1-33-16-17-35-20-21-36-19-18-34-15-14-29-27(31)12-13-28(32)30-22-25-8-3-2-6-23(25)10-11-24-7-4-5-9-26(24)30/h2-9H,12-22H2,1H3,(H,29,31) | [InChIKey]
CUEOILOXVJZHLK-UHFFFAOYSA-N | [SMILES]
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOC |
| Hazard Information | Back Directory | [Description]
m-PEG4-DBCO is a click chemistry reagents which can enable so called copper-free Click Chemistry with azide to form a stable triazole. | [Uses]
m-PEG4-NH-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG4-NH-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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