| Identification | Back Directory | [Name]
Methyl maslinate | [CAS]
22425-82-7 | [Synonyms]
Methyl maslinate
Methyl 2α-hydroxyoleanolate
(2α,3β)-2,3-Dihydroxy-olean-12-en-28-oic acid methyl ester
Olean-12-en-28-oic acid, 2,3-dihydroxy-, methyl ester, (2α,3β)-
(2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid methyl ester | [Molecular Formula]
C31H50O4 | [MOL File]
22425-82-7.mol | [Molecular Weight]
486.73 |
| Hazard Information | Back Directory | [Uses]
Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1]. | [in vivo]
Methyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1].
Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1]. | Animal Model: | Wistar male rats (300-320 g)[1] | | Dosage: | 20-60 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Showed significant, dose-response vasodepressor effect and sinus bradicardia.
Antagonized β-Adrenergic.
Showed antidysrhythmic activity.
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| [References]
[1] Somova LI, et al. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004 Feb;11(2-3):121-9. DOI:10.1078/0944-7113-00329 |
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