| Identification | More | [Name]
LITHIUM TRIETHYLBOROHYDRIDE | [CAS]
22560-16-3 | [Synonyms]
LITHIUM TRIETHYLBOROHYDRIDE
LITHIUM TRIETHYLHYDRIDOBORATE
LITHIUM TRIETHYLHYDROBORATE
SUPER-HYDRIDE(R)
lithiumtriethylborohydride,calselect?lt,
lithiumtriethylborohydride,calselect?lt,intetrahydrofuran
super-hydride (lithium triethylboro-hydride
Lithium borohydride thiethyl
Lithium triethylborohydride, in tetrahydrofuran, 1M solution
LITHIUM TRIETHYLBOROHYDRIDE-SOL. 1 M IN
LITHIUM TRIETHYLBOROHYDRIDE-SOL., 1 M IN THF, PACK. A 800 ML
SUPER-HYDRIDE (LITHIUM TRIETHYLBORO-HYDR IDE, 1.0M SOLUTION IN THF)
Lithium triethylborohydride, 1M solution in THF
Borate(1-), triethylhydro-, lithium, (T-4)-
lithium triethylborohydride solution
lithium triethylhydridoborate, 1m in thf
lithium triethylhydridoborate, 1m in thf, packaged under argon in resealable chemseal
super-hydride solution
Lithiumtriethylhydroborat
LITHIUM TRITHYLBOROHYDRIDE IN TETRAHYDROFURAN | [EINECS(EC#)]
245-076-8 | [Molecular Formula]
C6H16BLi | [MDL Number]
MFCD00011703 | [Molecular Weight]
105.94 | [MOL File]
22560-16-3.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to light grey cloudy solution | [Melting point ]
66-67° (Binger); mp 78-83° (dec) (Brown, 1977) | [density ]
0.892 g/mL at 25 °C
| [Fp ]
1 °F
| [storage temp. ]
Flammables + water-Freezer (-20°C)e area | [solubility ]
Miscible with tetrahydrofuran and benzene. | [form ]
Liquid | [color ]
Colorless to light gray | [Sensitive ]
Air & Moisture Sensitive | [Merck ]
14,5544 | [BRN ]
4151240 | [Exposure limits]
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) | [InChI]
InChI=1S/C6H13B.Li/c1-4-7(5-2)6-3;/h4-7H,1-3H3;/q-1;+1 | [InChIKey]
NOLZOGXVNKCSTH-UHFFFAOYSA-N | [SMILES]
[B+3]([H-])([CH-]C)([CH-]C)[CH-]C.[Li+] | [CAS DataBase Reference]
22560-16-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS02,GHS05,GHS07,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H318-H333-H225-H260-H302-H314-H335-H351 | [Precautionary statements ]
P210-P231+P232-P280-P370+P378-P402+P404-P403+P235-P223-P303+P361+P353-P305+P351+P338-P405-P501a | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R14/15:Reacts violently with water, liberating extremely flammable gases .
R19:May form explosive peroxides.
R34:Causes burns. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S33:Take precautionary measures against static discharges .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3399 4.3/PG 1
| [WGK Germany ]
1
| [F ]
10-23 | [REACH Registrations]
Active | [HazardClass ]
4.3 | [PackingGroup ]
I | [HS Code ]
29319090 | [Storage Class]
4.3 - Hazardous materials which set free flammable gases upon contact with water | [Hazard Classifications]
Acute Tox. 4 Oral
Carc. 2
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B
STOT SE 3
Water-react 1 |
| Hazard Information | Back Directory | [Description]
Lithium triethylborohydride is the organoboron compound with the formula LiEt3BH. Commonly referred to as LiTEBH or Superhydride, it is a powerful reducing agent used in organometallic and organic chemistry. It is a colorless or white liquid but is typically marketed and used as a THF solution. The related reducing agent sodium triethylborohydride is commercially available as toluene solutions.
LiBHEt3 is a stronger reducing agent than lithium borohydride and lithium aluminium hydride. | [Chemical Properties]
colorless to light grey cloudy solution | [Uses]
Powerful and selective reducing agent.
As a reducing agentLithium triethylborohydride is used as a powerful reducing agent in organic synthesis for the conversion of carbonyl compounds to alcohols. It is also used in the preparation of alkynyl alcohols from the cleavage of cyclic keto-vinyl triflates. It is also used in the reduction of esters and lactones to alcohol and diol respectively. Further, it is used to prepare 1-methylcyclohexanol and 1,4-butanediol from 1,2-epoxybutane and gamma-butyrolactone respectively. It is also utilized for reductive cleavage of mesylates and tosylates in synthetic organic chemistry. | [Application]
Lithium Triethylborohydride (LiTEBH) is widely used as a powerful and selective reducing agent that shows super hydride activity in organic synthesis.
LiTEBH can be used as a reagent:
To reduce alkyl halides to alkanes via dehydrogenation reactions.
For the selective reduction of epoxides to Markovnikov alcohols.
To reduce tosylates or mesylates primary alcohols to hydrocarbons.
For reductive cyclization reactions for the preparation of useful intermediates.
In the synthesis of hepta(manno-3-deoxy-6-O-t-butyldimethylsilyl)-β-cyclodextrin by reduction of hepta(manno-2,3-anhydro-6-O-t-butyldimethylsilyl)-β-cyclodextrin.
For hydrodefluorination of C-F bonds using Ni catalyst.
To prepare alkynyl alcohols from cleavage of cyclic keto-vinyl triflates.
In the stereoselective reduction of bicyclic imides, isoquinolines, and pyridines.
To prepare tungsten and molybdenum hydride complexes. | [Preparation]
LiBHEt3 is prepared by the reaction of lithium hydride (LiH) and triethylborane (Et3B) in tetrahydrofuran (THF):
LiH + Et3B → LiEt3BH
Its THF solutions are stable indefinitely in the absence of moisture and air. | [General Description]
Super-Hydride? solution (Lithium triethylborohydride or LiTEBH) is widely used as a powerful and selective reducing agent that shows super hydride activity in organic synthesis. | [reaction suitability]
reagent type: reductant | [Precautions]
Moisture sensitive. Air sensitive. Incompatible with water and strong oxidizing agents. | [References]
Tamang, S.; Kim, K.; Choi, H.; Kim, Y.; Jeong, S. Synthesis of colloidal InSb nanocrystals via in situ activation of InCl3. Dalton Trans. 2015, 44 (38), 16923-16928.
Kandapallil, B.; Colborn, R. E.; Bonitatibus, P. J.; Johnson, F. Synthesis of high magnetization Fe and FeCo nanoparticles by high temperature chemical reduction. J. Magn. Magn. Mater. 2015, 378, 535-538. |
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