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478-01-3

478-01-3 Structure

478-01-3 Structure
IdentificationMore
[Name]

NOBILETIN
[CAS]

478-01-3
[Synonyms]

3',4',5,6,7,8-HEXAMETHOXYFLAVONE
NOBILETIN
Flavone, 5,6,7,8,3',4'-hexamethoxy
hexamethoxyflavone
NOBILETIN WITH HPLC
NOBILETIN, 20% (TECHNICAL GRADE)
4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-
5,6,7,8-tetramethoxy-
Nobiletin,Hexamethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
[Molecular Formula]

C21H22O8
[MDL Number]

MFCD03273560
[Molecular Weight]

402.39
[MOL File]

478-01-3.mol
Questions And AnswerBack Directory
[Description]

Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

[Source]

Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).
[Uses]

NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation.
[structure and hydrogen bonding]

The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups.
[Application]

Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance.
Chemical PropertiesBack Directory
[CAS DataBase Reference]

478-01-3(CAS DataBase Reference)
Safety DataBack Directory
[HS Code ]

29329990
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