| Identification | More | [Name]
6-Hydroxy-1-naphthoic acid | [CAS]
2437-17-4 | [Synonyms]
2-NAPHTHOL-5-CARBOXYLIC ACID
6-HYDROXY-1-NAPHTHOIC ACID
OHNA
6-Hydroxynaphthoic acid
6-hydroxynaphthalene-1-carboxylic acid
6-HYDROXY-1-NAPHTHOIC ACID 95+%
6-Hydroxy-1-naphthalenecarboxylic acid | [EINECS(EC#)]
407-390-5 | [Molecular Formula]
C11H8O3 | [MDL Number]
MFCD00209983 | [Molecular Weight]
188.18 | [MOL File]
2437-17-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light yellow crystal powde | [Melting point ]
210°C | [Boiling point ]
445.7±18.0 °C(Predicted) | [density ]
1.399±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
3.76±0.10(Predicted) | [color ]
White to Brown | [InChI]
InChI=1S/C11H8O3/c12-8-4-5-9-7(6-8)2-1-3-10(9)11(13)14/h1-6,12H,(H,13,14) | [InChIKey]
JCJUKCIXTRWAQY-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)=C2C(C=C(O)C=C2)=CC=C1 | [CAS DataBase Reference]
2437-17-4(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
Preparation of 6-hydroxy-1-naphthoic acid: In a 250ml four-necked flask, add 20g of furoic acid, 19.3g of anisole, and 100ml of chlorobenzene, and stir to mix; heat in an oil bath to an internal temperature of 35-40℃, and slowly add 55.9g of anhydrous aluminum trichloride; after the addition is complete, stir and react at 75-80℃ for about 24 hours; cool down, concentrate under reduced pressure to distill off the chlorobenzene; after distillation is complete, cool to room temperature, and add 60ml of [unspecified substance] to the reaction flask. N,N-Dimethylformamide was stirred and mixed. Then, 32.1 g of anhydrous aluminum trichloride was slowly added in portions at room temperature. After the addition was complete, the mixture was heated in an oil bath to an internal temperature of 135°C and maintained at this temperature for 6 hours. The mixture was then cooled to room temperature with ambient water. The reaction solution was slowly added to a dilute hydrochloric acid solution for hydrolysis. The mixture was extracted several times with ethyl acetate, and the ethyl acetate extracts were combined, washed with water, and the pH was adjusted to weakly acidic. The organic layer was concentrated under reduced pressure, and the ethyl acetate was recovered. The residue was decolorized and recrystallized from dilute alcohol and water to give 14.6 g of 6-hydroxy-1-naphthoic acid powder in gray to pale yellow form. Yield: 43.5%, melting point: 204.5–208.7°C, purity: 98.5%. | [Application]
6-Hydroxy-1-naphthoic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [REACH Registrations]
Inactive | [HS Code ]
29182900 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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