| Identification | More | [Name]
Pamoic acid | [CAS]
130-85-8 | [Synonyms]
2,2'-DIHYDROXY-1,1'-DINAPHTHYLMETHANE 3,3'-DICARBOXYLIC ACID
4-[(3-CARBOXY-2-HYDROXY-NAPHTHALEN-1-YL)METHYL]-3-HYDROXY-NAPHTHALENE-2-CARBOXYLIC ACID
4-4'-METHYLENE-BIS-[2-HYDROXY-3-NAPHTHOIC ACID]
4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID)
4,4-METHYLENEBIS[3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID]
4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID)
4,4-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID)
4,4'-METHYLENE BIS-(3-HYDROXY-2-NAPTHOIC ACID)
EMBIONIC ACID
EMBONIC ACID
PAMOIC ACID
4,4’-methylenebis(3-hydroxy-2-naphthalenecarboxylicaci
4,4’-methylenebis(3-hydroxy-2-naphthoicaci
4,4’-methylenebis[3-hydroxy-2-naphthalenecarboxylicaci
3,3-dihydroxy-4,4-methylenedi(2-naphthoic acid)
Embonic acid~4,4-Methylenebis(3-hydroxy-2-naphthoic acid)
PAMOIC ACID FREE ACID
PamoicAcid98%
Pamoic
2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy- | [EINECS(EC#)]
204-998-0 | [Molecular Formula]
C23H16O6 | [MDL Number]
MFCD00004079 | [Molecular Weight]
388.37 | [MOL File]
130-85-8.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to yellow-green crystalline powder | [Melting point ]
≥300 °C (dec.)
| [Boiling point ]
434.1°C (rough estimate) | [density ]
1.2472 (rough estimate) | [refractive index ]
1.4593 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in nitrobenzene, pyridine | [form ]
Crystalline Powder | [pka]
2.67±0.30(Predicted) | [color ]
Yellow to yellow-green | [Water Solubility ]
PRACTICALLY INSOLUBLE | [Merck ]
14,7005 | [BRN ]
901319 | [InChI]
1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29) | [InChIKey]
WLJNZVDCPSBLRP-UHFFFAOYSA-N | [SMILES]
OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O | [CAS DataBase Reference]
130-85-8(CAS DataBase Reference) | [EPA Substance Registry System]
130-85-8(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P305+P351+P338-P261-P280a-P304+P340-P405-P501a | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R48:Danger of serious damage to health by prolonged exposure.
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
QL2180000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29182990 | [Storage Class]
11 - Combustible Solids | [Toxicity]
eye-rbt 100 mg MOD FCTOD7 20,573,82 |
| Hazard Information | Back Directory | [Chemical Properties]
Pamoic acid is yellow to yellow-green crystalline powder
| [Uses]
Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time
fluorescence enzymatic characterization study of specialized human DNA polymerases. | [Definition]
ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-). | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Biological Activity]
(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes. | [Safety Profile]
Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|