| Identification | Back Directory | [Name]
2,2'-OXYDIANILINE | [CAS]
24878-25-9 | [Synonyms]
2,2'-OXYDIANILINE
2,2’-Oxydlaniline
2-AMINOPHENYL ETHER
2,2'-OXYDIANILINE
Aniline, 2,2'-oxydi-
Olanzapine Impurity 33
2,2'-Oxybis(benzenamine)
Bis(2-aminophenyl) ether
2-(2-aminophenoxy)aniline
Benzenamine, 2,2'-oxybis-
2,2'-Diaminodiphenyl ether
2,2'-OXYDIANILINE in stock Factory
2,2′-Oxydianiline,2-Aminophenyl ether | [Molecular Formula]
C12H12N2O | [MDL Number]
MFCD00792533 | [MOL File]
24878-25-9.mol | [Molecular Weight]
200.24 |
| Chemical Properties | Back Directory | [Melting point ]
61-64 °C(lit.)
| [Boiling point ]
148.5-149.5 °C(Press: 0.3 Torr) | [density ]
1.216 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
4.15±0.10(Predicted) | [color ]
White to pale brown | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C12H12N2O/c13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)14/h1-8H,13-14H2 | [InChIKey]
GOJFAKBEASOYNM-UHFFFAOYSA-N | [SMILES]
O(C1=CC=CC=C1N)C1=CC=CC=C1N |
| Hazard Information | Back Directory | [Uses]
It is catalytic reagent and used in pharmaceutical industry. | [Synthesis]
General procedure for the synthesis of 2,2'-diaminodiphenyl ether from 2,2'-oxo-bis(nitrobenzene): first, an aqueous suspension of iron powder and hydrochloric acid was refluxed under stirring for 25 minutes. Subsequently, the corresponding dinitro compound was added to this hot suspension and the reflux reaction was continued for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and hydrolyzed with 20 mL of 2.5 M sodium hydroxide solution. Next, the reaction mixture was extracted with chloroform (20 mL each time, twice). The organic phases were combined, dried with anhydrous sodium sulfate and finally the solvent was evaporated to give the target product 2,2'-diaminodiphenyl ether as a solid. | [References]
[1] Tetrahedron, 1995, vol. 51, # 2, p. 579 - 590
[2] Polyhedron, 2015, vol. 90, p. 165 - 174
[3] Synthesis, 1996, # 8, p. 930 - 940
[4] Journal of Organic Chemistry, 1994, vol. 59, # 24, p. 7306 - 7315
[5] Zeitschrift fur Anorganische und Allgemeine Chemie, 2015, vol. 641, # 1, p. 128 - 135 |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|