ChemicalBook--->CAS DataBase List--->57260-71-6

57260-71-6

Request For Quotation
57260-71-6 Structure

57260-71-6 Structure
IdentificationMore
[Name]

tert-Butyl 1-piperazinecarboxylate
[CAS]

57260-71-6
[Synonyms]

1-BOC-PIPERAZINE
1-N-BOC-PIPERAZINE
1-(TERT-BUTOXYCARBONYL)PIPERAZINE
BOC-PAZ
BOC-PIPERAZINE
BUTTPARK 52\11-35
N-BOC-PIPERAZINE
N-(T-BOC)PIPERAZINE
N-T-BUTOXYCARBONYLPIPERAZINE
N-(TERT-BUTOXYCARBONYL)PIPERAZINE
N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE
PIBOC
PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
RARECHEM AR PA 0026
TERT-BUTYL 1-PIPERAZINECARBOXYLATE
TERT-BUTYL N-PIPERAZINE
TERT-BUTYL PIPERAZINE-1-CARBOXYLATE
TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
t-Butyl 1-piperazincarboxylate
1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
[EINECS(EC#)]

611-489-0
[Molecular Formula]

C9H18N2O2
[MDL Number]

MFCD00075265
[Molecular Weight]

186.25
[MOL File]

57260-71-6.mol
Chemical PropertiesBack Directory
[Appearance]

Waxy Solid
[Melting point ]

43-47 °C(lit.)
[Boiling point ]

98-100
[density ]

1.030±0.06 g/cm3(Predicted)
[Fp ]

>230 °F
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

Soluble in DMSO
[form ]

Low Melting Crystalline Mass
[pka]

8.45±0.10(Predicted)
[color ]

White to light yellow
[Water Solubility ]

Soluble in ethyl acetate, methanol and water.
[Sensitive ]

Air Sensitive
[Detection Methods]

MS,NMR,HPLC
[BRN ]

879985
[InChI]

1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
[InChIKey]

CWXPZXBSDSIRCS-UHFFFAOYSA-N
[SMILES]

CC(C)(C)OC(=O)N1CCNCC1
[CAS DataBase Reference]

57260-71-6(CAS DataBase Reference)
[NIST Chemistry Reference]

T-butyl 1-piperaziencarboxylate(57260-71-6)
Questions And AnswerBack Directory
[Uses]

N-Boc-piperazine is a compound useful in organic synthesis.
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[RIDADR ]

3263
[WGK Germany ]

3
[F ]

3-10-34
[Hazard Note ]

Irritant
[REACH Registrations]

Active
[HazardClass ]

IRRITANT
[HS Code ]

29335900
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Sodium hydroxide-->Methanol-->Dichloromethane-->Petroleum ether-->Di-tert-butyl dicarbonate-->Piperazine
[Preparation Products]

1-Boc-4-(2-formylphenyl)piperazine-->1-(Cyclopropylmethyl)piperazine-->1-(2-Methoxyethyl)piperazine-->N-Boc-4-(Cyclopropylmethyl)piperazine-->1-Boc-4-(4-formylphenyl)piperazine-->1-(2-Pyrazinyl)-piperazine-->tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%-->1-(3-Chlorphenyl)piperazine-->tert-Butyl 4-(5-formylpyrid-2-yl)piperazine-1-carboxylate-->Piperazine-1,4-dicarboxylic acid tert-butyl ester methyl ester-->1303512-02-8-->4-(2-Bromo-phenyl)-piperazine-1-carboxylic acid tert-butyl ester-->4-(5-Aminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester-->4-(2-Bromoethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester-->4-(3-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester-->Trimetazidine
Hazard InformationBack Directory
[Chemical Properties]

Waxy Solid
[Application]

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
[General Description]

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
[Synthesis]

The current method of synthesizing 1-tert-butoxycarbonylpiperazine is mainly to use anhydrous piperazine drops with di-tert-butyl dicarbonate selective reaction of the nitrogen at one end of the piperazine is protected so that the other end of the amin

Spectrum DetailBack Directory
[Spectrum Detail]

tert-Butyl 1-piperazinecarboxylate(57260-71-6)1HNMR
tert-Butyl 1-piperazinecarboxylate(57260-71-6)FT-IR
tert-Butyl 1-piperazinecarboxylate(57260-71-6)IR
tert-Butyl 1-piperazinecarboxylate(57260-71-6)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

tert-Butyl 1-piperazinecarboxylate, 97%(57260-71-6)
[Alfa Aesar]

1-Boc-piperazine, 99%(57260-71-6)
[Sigma Aldrich]

57260-71-6(sigmaaldrich)
[TCI AMERICA]

1-(tert-Butoxycarbonyl)piperazine,>98.0%(GC)(T)(57260-71-6)
57260-71-6 suppliers list
Company Name: Hubei Jingxiang Technology Co., Ltd.  Gold
Telephone: 18136494513 13347833233
Website:
Company Name: Anhui Dexinjia Biopharm Co., Ltd  Gold
Telephone: 0531-82375893 15553111391
Website: www.ahdxj.com/
Company Name: Chengdu Firster Pharmaceutical Co., Ltd.  Gold
Telephone: 028-87078428 028-87074958
Website: http://www.cdfirster.com
Company Name: Shanghai Hobor Chemical Co., Ltd  Gold
Telephone: 13918007836
Website: www.chemicalbook.com/supplier/10604232/
Company Name: Nanjing Yihua Biotechnology Co., Ltd  Gold
Telephone: 18168057470
Website: www.chemicalone.com/
Company Name: Xiamen Ruiyuxin Biotechnology Co., Ltd  Gold
Telephone: 0598-5501589 15392323620
Website:
Company Name: Zhejiang Aobang Pharmaceutical & Chemical Co. LTD  Gold
Telephone: 13676682222 13676682222;
Website: https://www.chemicalbook.com/ShowSupplierProductsList261328/0_EN.htm
Company Name: Nanjing Yili Biotechnology Co., Ltd.  Gold
Telephone: 13851808754
Website: www.buysellchem.com/
Company Name: Anqing CHICO Pharmaceutical Co., Ltd.  Gold
Telephone: 18061456370
Website: www.chicopharm.cn/
Company Name: Shanghai Jingfu Biotechnology Co., LTD  Gold
Telephone: 0598-5859955 13313739955
Website: http://www.jingfubio.com/
Company Name: Shanghai Tuolei Chemical Reagents Co., Ltd.  
Telephone: 86-021-50318510
Website: www.chemicalbook.com/ShowSupplierProductsList13028/0_EN.htm
Company Name: J & K SCIENTIFIC LTD.  
Telephone: 18210857532 18210857532
Website: https://www.jkchemical.com
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Telephone: 4006356688 18621169109
Website: www.x-labseek.com/
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Telephone: 18930552037
Website: www.chemicalbook.com/showsupplierproductslist13285/0_en.htm
Company Name: Shanghai Targsense Scientific Co., Ltd.  
Telephone: 18916626092
Website: http://www.targsense.com
Company Name: Alfa Aesar  
Telephone: 400-6106006
Website: http://chemicals.thermofisher.cn
Company Name: TAIYUAN RHF CO.,LTD.  
Telephone: +86 351 7031519
Website: www.rhfchem.com
Company Name: TCI (Shanghai) Development Co., Ltd.  
Telephone: 021-67121386
Website: https://www.tcichemicals.com/CN/zh/
Tags:57260-71-6 Related Product Information
140-31-8 1138-80-3 69327-76-0 110-85-0 84-74-2 61477-96-1 122008-85-9 171876-65-6 75-65-0 142-77-8 76535-74-5 2592-95-2 632-22-4 420846-72-6 763111-47-3 142-64-3 179897-89-3 4023-34-1