| Identification | Back Directory | [Name]
2,2'-Oxybis(nitrobenzene) | [CAS]
2217-65-4 | [Synonyms]
Olanzapine Impurity 34
2,2'-Oxybis(nitrobenzene)
2,2'-Oxybis(nitrobenzdene)
Benzene, 1,1'-oxybis[2-nitro- | [Molecular Formula]
C12H8N2O5 | [MDL Number]
MFCD00033880 | [MOL File]
2217-65-4.mol | [Molecular Weight]
260.2 |
| Chemical Properties | Back Directory | [Melting point ]
114.5 °C | [Boiling point ]
185 °C(Press: 15 Torr) | [density ]
1.416±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature |
| Hazard Information | Back Directory | [Synthesis]
General procedure: 1-fluoro-2-nitrobenzene (1.0 mmol) was used as a feedstock, and tributylphosphine (PBu3, 2.0 mmol), palladium acetate (Pd(OAc)2, 2 mol%), and potassium carbonate/zirconium oxide (K2CO3/ZrO2, 1.5 equiv, based on K2CO3, 2.070 g) were added in xylene (10 mL). The mixture was stirred at reflux under nitrogen protection for 24 hours or until TLC showed that the reaction was complete. After completion of the reaction, the mixture was filtered and washed with dichloromethane (DCM). The organic layers were combined and the solvent was removed by evaporation. The product was purified by column chromatography using dichloromethane/hexane (1:1 to 1:2) as eluent to give the target product 2,2'-oxobis(nitrobenzene). | [References]
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992, # 3, p. 377 - 382
[2] Chemistry - An Asian Journal, 2015, vol. 10, # 2, p. 468 - 473
[3] Journal of Chemical Research, 2016, vol. 40, # 11, p. 691 - 693
[4] Journal of Organic Chemistry, 2018, vol. 83, # 24, p. 14882 - 14893 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|