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25456-75-1

Example 1: Synthesis of Di-tert-butyl Glutamate 10 g (68 mmol) of 2-aminoglutaric acid (glutamic acid) was suspended in 290 mL of tert-butyl acetate, 16.6 mL (0.15 mol) of 60% perchloric acid solution was added, and the solution was shaken for about 15 minutes until completely dissolved. The reaction solution was left to react at room temperature for 5 days. After completion of the reaction, the mixture was cooled to -5 °C (ice/NaCl bath) and extracted (4 times) with 0.5 N hydrochloric acid solution. The aqueous phase was neutralized to pH neutral with solid sodium carbonate and subsequently extracted with ether (6 times). All organic phases were combined, washed with saturated aqueous sodium bicarbonate solution (2 times), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 3.5 g (20% yield) of di-tert-butyl glutamate, the product was a light yellow liquid.