| Identification | Back Directory | [Name]
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- | [CAS]
2561494-77-5 | [Synonyms]
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- | [Molecular Formula]
C24H21N5O4 | [MDL Number]
MFCD32867310 | [MOL File]
2561494-77-5.mol | [Molecular Weight]
443.46 |
| Chemical Properties | Back Directory | [Boiling point ]
697.2±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (>25 mg/ml) | [form ]
solid | [pka]
10.91±0.70(Predicted) | [color ]
Pale yellow | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2).? It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2.? UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases.? Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 μM). | [Uses]
UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization. | [storage]
Store at -20°C | [References]
Dilworth et al. (2022), A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization; Nat. Chem. Biol., 18 56 |
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