| Identification | Back Directory | [Name]
(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | [CAS]
256411-32-2 | [Synonyms]
CKD-602
Belotecan
Camtobell
CKD602/CAMTOBELL
LNHWXBUNXOXMRL-VWLOTQADSA-N
BELOTECAN; CKD 602; CKD-602
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, (4S)-
(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | [Molecular Formula]
C25H27N3O4 | [MOL File]
256411-32-2.mol | [Molecular Weight]
433.5 |
| Chemical Properties | Back Directory | [Boiling point ]
772.4±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.24±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Antineoplastic
(DNA topoisomerase I inhibitor). | [Definition]
ChEBI:Belotecan is a pyranoindolizinoquinoline. | [in vivo]
Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice[1]. | Animal Model: | BALB/c-nude mice with CaSki cells injection[1] | | Dosage: | 25 mg/kg | | Administration: | Intravenous injection; 25 mg/kg; 16 days at 4-day intervals | | Result: | Significantly inhibited the tumor growth and showed no significant difference in bodyweight of xenograft mice and the controls.
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Abydos Scientific
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| Tel: |
025-84767922 18936879710 |
| Website: |
http://www.abydoscientific.com/index.html |
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