| Identification | Back Directory | [Name]
UK-371804 hydrochloride | [CAS]
256476-36-5 | [Synonyms]
UK-371804 HCl
UK-371804 hydrochloride
UK-371,804 HCl >=98% (HPLC) | [Molecular Formula]
C14H17Cl2N5O4S | [MDL Number]
MFCD31558512 | [MOL File]
256476-36-5.mol | [Molecular Weight]
422.28 |
| Chemical Properties | Back Directory | [Melting point ]
258 °C (decomp) | [storage temp. ]
-20°C | [solubility ]
DMSO: 42 mg/mL (99.46 mM);Ethanol: Insoluble | [form ]
powder | [color ]
white to beige | [Water Solubility ]
Water: Insoluble | [InChI]
1S/C14H16ClN5O4S.ClH/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15;/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19);1H | [InChIKey]
IUBFETAFRGVODB-UHFFFAOYSA-N | [SMILES]
CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl |
| Hazard Information | Back Directory | [Uses]
UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM[1]. | [Biochem/physiol Actions]
UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins. | [References]
[1] Paul V Fish, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007, 50, 10. DOI:10.1021/jm061066t |
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