| Identification | Back Directory | [Name]
Taspoglutide | [CAS]
275371-94-3 | [Synonyms]
R-1583
ITM-077
BIM-51077
taspoglutide
Taspoglutide Acetate
ITM-077;R-1583;BIM-51077
7-36-Glucagon-like peptide I (human), 8-(2-methylalanine)-35-(2-methylalanine)-36-L-argininamide- | [Molecular Formula]
C152H232N40O45 | [MDL Number]
MFCD13195564 | [MOL File]
275371-94-3.mol | [Molecular Weight]
3339.71 |
| Chemical Properties | Back Directory | [density ]
1.46 | [storage temp. ]
-20°C | [solubility ]
DMSO : ≥ 28 mg/mL (8.38 mM) | [form ]
lyophilized powder | [color ]
white to beige | [Sequence]
H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2 | [InChIKey]
WRGVLTAWMNZWGT-NZRVKQFPNA-N |
| Hazard Information | Back Directory | [General Description]
Taspoglutide with -methylalanine in greatly retard degradation by DPP-IV and neutral endopeptidase24.11, respectively (see preceding discussion for exenatide).The phase III trials, which commenced in 2008, arebeing conducted with a zinc-based preparation, prolongingthe duration in a manner similar to zinc-containing insulinpreparations, so that once-weekly injections of 20 to 30 mgwill be possible. | [Biological Activity]
Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist. Taspoglutide improves glucose tolerancepostprandial glucosebody weightglycaemic control and insulin sensitivity in the Zucker diabetic fatty rat. | [storage]
Store at -20°C |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
|