| Identification | Back Directory | [Name]
Masoprocol | [CAS]
27686-84-6 | [Synonyms]
CHX-100
masoprocol
NORHYDROGUAIARETICACID
Masoprocol(nordihydroguaiaretic)
meso-4，4'-(2，3- Dimethyltetramethylene)dipyrocatechol
(R*,S*)-4,4'-(2,3-dimethylbutane-1,4-diyl)bispyrocatechol
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol
4,4'-((2R,3S)-2,3-DiMethylbutane-1,4-diyl)bis(benzene-1,2-diol)
4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol
rel-4,4'-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)
4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol | [EINECS(EC#)]
248-606-6 | [Molecular Formula]
C18H22O4 | [MDL Number]
MFCD00866548 | [MOL File]
27686-84-6.mol | [Molecular Weight]
302.365 |
| Hazard Information | Back Directory | [Description]
Masoprocol is a lipoxygenase inhibitor launched as a topical agent for the treatment of
solar or actinic keratoses. It is the first new topical treatment for pre-malignant skin
lesions introduced in twenty years. Masoprocol is obtained from the Larrea tridentata
plant and is also under investigation for the treatment of lung, breast, colon and ovarian cancers. | [Chemical Properties]
Crystallized from acetic acid, melting point 185-186°C. UV absorption maximum (methanol): 283, 218nm (ε6660, 13400). Soluble in ethanol, methanol, ether, or concentrated sulfuric acid, slightly soluble in hot water or chloroform, insoluble in petroleum ether, benzene, toluene, or dilute hydrochloric acid. Soluble in dilute alkali solution and turns red. | [Originator]
Chemex (U.S.A.) | [Uses]
Antineoplastic. | [Definition]
ChEBI: Masoprocol is the meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. It has a role as an antineoplastic agent, a lipoxygenase inhibitor, a hypoglycemic agent and a metabolite. | [Brand name]
Actinex (University Of Arizonia Cancer Center). |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
| Company Name: |
AmplaChem, Inc.
|
| Tel: |
+1 (412) 455-5567 |
| Website: |
www.amplacheminc.com |
|