| Identification | Back Directory | [Name]
CANTHARIDIC ACID | [CAS]
28874-45-5 | [Synonyms]
CANTHARIDIC ACID
CANTHARIDIC ACID DISODIUM SALT
Cantharidic Acid - CAS 28874-45-5 - Calbiochem
5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE | [Molecular Formula]
C8H10O5 | [MDL Number]
MFCD00047137 | [MOL File]
28874-45-5.mol | [Molecular Weight]
186.16 |
| Chemical Properties | Back Directory | [Melting point ]
216-218℃ | [Boiling point ]
407.8±40.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [storage temp. ]
+15C to +30C | [solubility ]
Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming) | [form ]
White solid | [pka]
3.70±0.40(Predicted) | [color ]
white | [InChI]
InChI=1/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10- | [InChIKey]
NMTNUQBORQILRK-XCVPVQRUNA-N | [SMILES]
[C@@]12([H])O[C@@]([H])(CC1)[C@](C)(C(O)=O)[C@]2(C)C(O)=O |&1:0,3,7,12,r| |
| Hazard Information | Back Directory | [Uses]
Potent and selective inhibitor of PP2A, IC50=53nM (IC50 for PP1=562nM). Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins. | [Definition]
ChEBI: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A. | [Biological Activity]
Cell permeable: no''Primary Target
PP2A''Product does not compete with ATP.''Reversible: no''Target IC50: 50 nM against protein phosphatase 2A | [storage]
Room temperature | [References]
[1] Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. DOI:10.1002/tox.22897 |
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
|