| Identification | More | [Name]
Thymopentin | [CAS]
69558-55-0 | [Synonyms]
ARG-LYS-ASP-VAL-TYR
(ASP34)-THYMOPOIETIN III (32-36) (BOVINE)
H-ARG-LYS-ASP-VAL-TYR-OH
RKDVY
THYMOPENTIN
THYMOPENTIN 5
THYMOPOIETIN (32-36) (HUMAN, MOUSE)
THYMOPOIETIN II FRAGMENT (32-36)
THYMOPOIETIN I/II (32-36) (BOVINE)
THYMOPOIETIN PENTAPEPTIDE
TP-5
Immunox
Sintomodulina
Thymopentin-FITC
Thymopoietin 32-36
Timunox
TP-5（Thymopentin）
Thymopentin TP-5
Thymopentine
THYMOPETIN | [EINECS(EC#)]
811-641-8 | [Molecular Formula]
C10H14OSn | [MDL Number]
MFCD00214200 | [Molecular Weight]
268.93 | [MOL File]
69558-55-0.mol |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
Powder | [pka]
3.07±0.10(Predicted) | [color ]
White | [Sequence]
Arg-Lys-Asp-Val-Tyr | [InChIKey]
PSWFFKRAVBDQEG-YGQNSOCVSA-N | [SMILES]
O=C([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC1C=CC(=CC=1)O)=O | [CAS DataBase Reference]
69558-55-0(CAS DataBase Reference) |
| Questions and Answers (Q&A) | Back Directory | [Description]
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
| [References]
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.
|
| Hazard Information | Back Directory | [Chemical Properties]
TP is a polypeptide extracted from the calf thymus. Two similar types have been identified: thymopoietin-I (TP-I) and thymopoietin-II (TP-II). TP-II is a 49-mer peptide composed of 13 amino acids. The structural difference between TP-I and TP-II is that the amino acids Se1 and Se43 in the TP-II peptide chain are replaced by Gly1 and Se43 in TP-I. The pentapeptide consisting of Se32-Thr36 has demonstrated T cell differentiation activity in vitro and in vivo. Five of the 49 amino acids are physiologically active. The synthetic lysine-valine penta-peptide, timopentin, has been synthesized and is currently in clinical use. Furthermore, splenin, isolated from bovine spleen, is similar to TP-II and is therefore designated TP-III. The synthetic TP-II penta-peptide is tentatively referred to as thymosynthetin (TPe), and the synthetic TP-III penta-peptide is tentatively referred to as splenosytin (SPe). TP-II and TPe act on neuromuscular transmission, inducing the in vitro differentiation of T cell precursors while inhibiting B cell differentiation. TP-III and SPe can induce the differentiation of T and B cell precursors. Ubiquitin, composed of 74 amino acid residues, can induce the differentiation of both T and B cells. It is widely present in animal tissues (including the thymus) and plant and fungal cells, and is associated with immune function. | [Originator]
Janssen (Belgium) | [Uses]
immunoregulator | [Definition]
ChEBI: Thymopentin is an oligopeptide. | [Brand name]
SINTOMODULINA; TIMUNOX | [Clinical Use]
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the
active fragment of the thymus hormone, thymopoietin. Thymopentin induces
phenotypic differentiation and maturation of T-cells. It appears of value in the
treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis,
sarcoidosis and a variety of other diseases with manifestations of disturbed
immune balance. |
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